Book chapters

 

(2016) Renan C. Chisté, Eduarda Fernandes. Bioactive compounds from Amazonian fruits and its antioxidant properties. (Chapter 8). In: Natural Bioactive Compounds from Fruits and Vegetables as Health Promoters, L.R. Silva and B. Silva (Eds), 1st Ed., Bentham Science Publishers, Pequim, China, 2016.

 

(2016) Eduarda Fernandes, Marisa Freitas, Renan C. Chisté, Elena Falqué, Herminia Domínguez. Grape polyphenol-rich products with antioxidant and anti-inflammatory properties (Chapter 25). In: Textbook of Oxidative Stress and Antioxidant Protection. The Science of Free Radical Biology and Disease, D. Armstrong, R. D. Stratton (Eds), 1st Ed., John Wiley & Sons, Inc., Corporate, Hoboken, New Jersey, EUA: 584 pages, March 2016. [Ahead of print]

 

(2006) R.M. Seabra; P.B. Andrade; P. Valentão; E. Fernandes; F. Carvalho; M.L. Bastos. Antioxidant Compounds Extracted From Several Plant Materials. In: Biomaterials From Aquactic and Terrestrial Organisms, ed. M. Fingerman; R. Nagabhushanam, Science Publishers, 115-174.

(2003) E. Fernandes; J.L.F.C Lima; S. Reis. Involvement of reactive oxygen and nitrogen species in inflammatory processes. Implications for the potential therapeutic use of NSAIDs with antioxidant activity. In: Current Topics in Medicinal Chemistry, eds. D.T.W. Chu; W.B. Gratzer; F. Halberg; P. Herdewijn, V.J. Hruby, J.A. Katzenellenbogen, A.J. Lin, V. Nacci, M.E. Nasr, C.H. Robison, D.F.Veber, D.A. Winkler, Research Trends, 3, 221-236.

 

 

Publication in peer reviewed journals in the last 5 years

 

2015

 

Renan C. Chisté, Marisa Freitas, Adriana Z. Mercadante, Eduarda Fernandes. Superoxide anion radical: generation and detection in cellular and non-cellular systems. Curr. Med. Chem., 22, 4234-4256, 2015.

 

Alessanda Berto, Alessandra B. Ribeiro, Nilson E. Souza, Eduarda Fernandes, Renan C. Chisté. Bioactive compounds and scavenging capacity of pulp, peel and seed extracts of the Amazonian fruit Quararibea cordata against ROS and RNS. Food Res. Int., 77, 236-243, 2015.

 

Diana Couto, Marisa Freitas, Graça Porto, M. Arturo Lopez-Quintela, José Rivas, Paulo Freitas, Félix Carvalho, Eduarda Fernandes. Polyacrylic acid-coated and non-coated iron oxide nanoparticles induce cytokine activation in human blood cells through TAK1, p38 MAPK and JNK pro-inflammatory pathways. Arch. Toxicol., 89, 1759-1769, 2015.

 

Paula Silva, Eduarda Fernandes, Félix Carvalho. Dual effect of red wine on liver redox status: a concise and mechanistic review. Arch. Toxicol., 89, 1681-1693, 2015. 

 

Alessanda Berto, Alessandra B. Ribeiro, Enrique Sentandreu,  Nilson E. Souza, Adriana Z. Mercadante, Renan C. Chisté, Eduarda Fernandes. The seed of the Amazonian Fruit Couepia bracteosa exhibits higher scavenging capacity against ROS and RNS than its shell and pulp extracts. Food Funct., 6, 3081-3090, 2015.

 

Daniela Ribeiro, Marisa Freitas, José L.F.C. Lima, Eduarda Fernandes. Proinflammatory pathways: The modulation by flavonoids. Med Res Rev., 35, 877-936, 2015.

 

Diana Couto, Marisa Freitas, Félix Carvalho, Eduarda Fernandes. Iron Oxide Nanoparticles: an Insight into their Biomedical Applications. Curr Med Chem., 22, 1808-1828, 2015.

 

Alessandra B. Ribeiro, Alessandra Berto, Renan C. Chisté, Marisa Freitas, Jesuí V. Visentainer, Eduarda Fernandes. Stem bark and flower extracts of Vismia cauliflora are highly effective antioxidants to human blood cells by preventing oxidative burst in neutrophils and oxidative damage in erythrocytes. Pharm. Biol., 53, 1691-1698, 2015.

 

Alessandra B. Ribeiro, Alessandra Berto, Renan C. Chisté, Marisa Freitas, Jesuí V. Visentainer, Eduarda Fernandes. Bioactive compounds and scavenging capacity of extracts from different parts of Vismia cauliflora plant against reactive oxygen and nitrogen species. Pharm. Biol., 53, 1267-1276, 2015.

 

Gomes A, Capela JP, Ribeiro D, Freitas M, Silva AM, Pinto DC, Santos CM, Cavaleiro JA, Lima JL, Fernandes E. Inhibition of NF-kB Activation and Cytokines Production in THP-1 Monocytes by 2-Styrylchromones. Med. Chem., 11, 560-566, 2015.

 

Couto D, Sousa R, Andrade L, Leander M, Lopez-Quintela MA, Rivas J, Freitas P, Lima M, Porto G, Porto B, Carvalho F, Fernandes E. Polyacrylic acid coated and non-coated iron oxide nanoparticles are not genotoxic to human T lymphocytes. Toxicol Lett., 234, 67-73, 2015.

 

João Rocha, Maria Eduardo-Figueira, Andreia Barateiro, Adelaide Fernandes, Dora Brites, Rui Pinto, Marisa Freitas, Eduarda Fernandes, Helder Mota-Filipe, Bruno Sepodes. Erythropoietin reduces acute lung injury and multiple organ failure/dysfunction associated to a scald-burn inflammatory injury in the rat. Inflammation, 38, 312-326, 2015.

 

João Rocha, Maria Eduardo-Figueira, Andreia Barateiro, Adelaide Fernandes, Dora Brites, Rui Pinto, Marisa Freitas, Eduarda Fernandes, Helder Mota-Filipe, Bruno Sepodes. Inhibition of glycogen synthase kinase 3[beta] (GSK-3[beta]) attenuates organ injury and dysfunction associated to liver ischemia-reperfusion and thermal injury in the rat. Shock, 43, 369-379, 2015.

 

João Rocha, Maria Eduardo-Figueira, Andreia Barateiro, Adelaide Fernandes, Dora Brites, Rosario Bronze, Catarina Duarte, Teresa Serra, Rui Pinto,Marisa Freitas, Eduarda Fernandes, Beatriz Silva-Lima, Helder Mota-Filipe, Bruno Sepodes. Anti-inflammatory effect of rosmarinic acid and an extract of Rosmarinus officinalis in rat models of local and systemic inflammation. Basic Clin. Pharmacol. Toxicol., 116, 398-413, 2015.

 

Daniela Ribeiro, Marisa Freitas, Sara M. Tomé, Artur M. Silva, Stefan Laufer, José L.F.C. Lima, Eduarda Fernandes. Flavonoids Inhibit COX-1 and COX-2 Enzymes and Cytokine/Chemokine Production in Human Whole Blood. Inflammation, 38, 858-870, 2015.

 

 

2014

 

Marisa Freitas, Daniela Ribeiro, Sara M. Tomé, Artur M. Silva, Eduarda Fernandes. Synthesis of chlorinated flavonoids  with anti-inflammatory and pro-apoptotic activities in human neutrophils. Eur. J. Med. Chem., 86, 153-164, 2014. 

 

Renan C. Chisté, Marisa Freitas, Adriana Z. Mercadante, Eduarda Fernandes. Carotenoids are effective inhibitors of in vitro hemolysis of human erythrocytes, as determined by a practical and optimized cellular antioxidant assay. J. Food Sci., 79, H1841-H1847, 2014.

 

Lilian R. B. Mariutti, Eliseu Rodrigues, Renan C. Chisté, Eduarda Fernandes, Adriana Z. Mercadante. The Amazonian fruit Byrsonima crassifolia effectively scavenges reactive oxygen and nitrogen species and protects human erythrocytes against oxidative damage. Food Res. Int., 64, 618-625, 2014.

 

Mariela Pistón, Ignacio Machado, Cátia S. Branco, Verónica Cesio, Horacio Heinzen, Daniela Ribeiro, Eduarda Fernandes, Renan C. Chisté, Marisa Freitas.Infusion, decoction and hydroalcoholic extracts of leaves from artichoke (Cynara cardunculus L. subsp. cardunculus) are effective scavengers of physiologically relevant ROS and RNS. Food Res. Int., 64, 150-156, 2014.

 

Alessandra Braga Ribeiro, Renan C. Chisté, Marisa Freitas, Alex F. Silva, Jesuí V. Visentainer, Eduarda Fernandes. Psidium cattleianum fruit extracts are efficient in vitro scavengers of physiologically relevant reactive oxygen and nitrogen species. Food Chem., 165, 140-148, 2014.

 

Renan C. Chisté, Marisa Freitas, Adriana Z. Mercadante, Eduarda Fernandes. Carotenoids inhibit lipid peroxidation and hemoglobin oxidation, but not the depletion of glutathione induced by ROS in human erythrocytes. Life Sci., 99, 52-60, 2014.

 

Daniel José Barbosa, Román Serrat, Serena Mirra, Martí Quevedo, Elena Goméz de Barreda, Jesús Ávila, Luísa Maria Ferreira, Paula Sério Branco, Eduarda Fernandes, Maria de Lourdes Bastos, João Paulo Capela, Eduardo Soriano, Félix Carvalho. The mixture of "ecstasy" and its metabolites impairs mitochondrial fusion/fission equilibrium and trafficking in hippocampal neurons, at in vivo relevant concentrations. Toxicol. Sci., 139, 407-420, 2014.

 

Daniel José Barbosa, Román Serrat, Serena Mirra, Martí Quevedo, Elena Goméz de Barreda, Jesús Ávila, Eduarda Fernandes, Maria de Lourdes Bastos, João Paulo Capela, Félix Carvalho, Eduardo Soriano. MDMA impairs mitochondrial neuronal trafficking in a Tau- and Mitofusin2/Drp1-dependent manner. Arch. Toxicol., 88, 1561-1572, 2014.

 

Daniel José Barbosa, João Paulo Capela, Renata Silva, Vânia Vilas-Boas, Luísa Ferreira, Paula Sério Branco, Eduarda Fernandes, Maria de Lourdes Bastos, Félix Carvalho, The mixture of "ecstasy" and its metabolites is toxic to human SH-SY5Y differentiated cells at in vivo relevant concentrations, Arch. Toxicol., 88, 455-473, 2014.

 

Daniel José Barbosa, João Paulo Capela Renata Silva, Luísa Ferreira, Paula Sério Branco, Eduarda Fernandes, Maria Lourdes Bastos, Félix Carvalho,Ecstasy-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites and their stability under normothermic and hyperthermicconditions, Arch. Toxicol., 88, 515-531, 2014.

 

Renan C. Chisté, Marta T. Benassi, Adriana Z. Mercadante. Efficiency of different solvents on the extraction of bioactive compounds from the Amazonian fruit Caryocar villosum and the effect on its antioxidant and colour properties. Phytochem. Anal., 25, 364-372, 2014.

 

Diana Couto, Marisa Freitas, Vânia Vilas-Boas, Irene Dias, Graça Porto, M. Arturo Lopez-Quintela, José Rivas, Paulo Freitas, Félix Carvalho, Eduarda Fernandes, Interaction of polyacrylic acid coated and non-coated iron oxide nanoparticles with human neutrophils, Toxicol. Lett., 225, 57-65, 2014.

 

Daniela Ribeiro, Marisa Freitas, Sara M. Tomé, Artur M.S. Silva, Graça Porto, Eurico J. Cabrita, M.Manuel B. Marques, Eduarda Fernandes, Inhibition of LOX by flavonoids: A structure-activity relationship study, Eur. J. Med. Chem., 72, 137-145, 2014.

 

 

2013

 

Maria Marques, Luisa Carvalho, Marina Pires and E. Fernandes, Pd-catalysed amination on soluble polymer support: arylation of anilines with PEG-supported aryl halides, RSC Adv., 3, 25711-25715, 2013.

 

Daniela Ribeiro, Marisa Freitas, Sara M. Tomé, Artur M. S. Silva, Graça Porto, Eduarda Fernandes. “Modulation of human neutrophils’ oxidative burst by flavonoids” . Eur. J. Med. Chem.,  67, 280-292, 2013.

 

Noelia Gonzalez, Daniela Ribeiro, Eduarda Fernandes, Daniele R. Nogueira, Enma Conde, Andrés Moure, María Pilar Vinardelli, Montserrat Mitjans, Hermínia Domínguez. Potential use of Cytisus scoparius extracts in tropical applications for skin protection against oxidative damage. J. Photochem. Photobiol B.,  125, 83-89, 2013.

 

Marisa Freitas, Vera M Costa, Daniela Ribeiro, Diana Couto, Graça Porto, Félix Carvalho, Eduarda Fernandes, Acetaminophen prevents oxidative burst and delays apoptosis in human neutrophils, Toxicol. Lett.,  219, 170-177, 2013.

 

Clementina M.M. Santos, M. Beatriz Q. Garcia, Artur M.S. Silva, René Santus, Patrice Morlière, Eduarda Fernandes, Electrochemical characterization of bioactive hydroxyxanthones by cyclic voltammetry, Tetrahedron Lett.,  54, 85-90, 2013.

 

Patrícia Silva Ferreira, Tiago Bernardes Nogueira, Vera Marisa Costa, Paula Sério Branco, Luísa Maria Ferreira, Eduarda Fernandes, Maria Lourdes Bastos, Andreas Meisel, Félix Carvalho, João Paulo Capela, Neurotoxicity of “ecstasy” and its metabolites in human dopaminergic differentiated SH-SY5Y cells, Toxicol. Lett., 216, 159-170, 2013.

 

Marisa Freitas, Pedro Barcellos-de-Souza, Christina Barja-Fidalgo, Eduarda Fernandes, Nickel induces apoptosis in human neutrophils, Biometals,  26, 13-21, 2013.

 

João Paulo Capela, Silvana da Costa Araújo, Vera Marisa Costa, Karsten Ruscher, Eduarda Fernandes, Maria Lourdes Bastos, Ulrich Dirnagl, Andreas Meisel, Félix Carvalho, The neurotoxicity of hallucinogenic amphetamines in primary cultures of hippocampal neurons, Neurotoxicology, 34, 254-263, 2013.

 

Port´s, P. S.; Renan Campos Chisté, Godoy, H. T.; Prado, M.A. The phenolic compounds and the antioxidant potential of infusion of herbs from the Brazilian Amazonian. Food Res. Int., 53, 875-881, 2013.

 

Vissotto, L.C.; Rodrigues, E; Renan Campos Chisté, Benassi, M.T.; Mercadante, A.Z. Correlation, by multivariate statistical analysis, between the scavenging capacity against reactive oxygen species and the bioactive compounds from frozen fruit pulps. Ciência e Tecnologia de Alimentos, 33 (supl 1), 57-65, 2013.

 

Mara Ribeiro Almeida, Darin, J.D.C.; Gomes, T.D.U.H.; Aissa, A.F.; Renan Campos Chisté, Adriana Z. Mercadante, Antunes, LMG; Bianchi, MLP. In vivo genotoxicity and oxidative stress evaluation of en ethanolic extract from piquiá (Caryocar villosum) pulp. J Med. Food, 16, 268-271, 2013.

 

 

2012

 

Paula Silva, M.J. Rocha, C. Cruzeiro, F. Malhão, B. Reis, R. Urbattzka, R.A.F. Monteiro, E. Rocha. Testing of ethinylestradiol and of an enviromentally relevant mixture of xenoestrogens as found in the Douro River (Portugal) on the maturation of fish gonads - A stereological study using the zebra fish (Danio rerio) as model. Aqua. Toxicol., 2012, 124-125, 1-10.

 

Barbosa D.J., Capela J.P., Oliveira J.M., Silva R., Ferreira L.M., Siopa F., Branco P.S., Fernandes E., Duarte J.A., Bastos M.D., Carvalho F., Pro-oxidant effects of ecstasy and its metabolites in mouse brain synaptosomes, Br. J. Pharmacol. 2012, 165, 1017-1033.

 

Patrice Morlière, Larry K. Patterson, Clementina M.M. Santos, Artur M.S. Silva, Jean-Claude Mazière, Paulo Filipe, Ana Gomes, Eduarda Fernandes, M. Beatriz Q. Garcia, René Santus, The dependence of α-tocopheroxyl radical reduction by hydroxy-2,3-diarylxanthones on structure and micro-environment, Org. Biomol. Chem. 2012, 10, 2068-2076.

 

Mónica S. Estevão, Filipe J. S. Duarte, Eduarda Fernandes, A. Gil Santos, M. Manuel B. Marques, Unexpected reactivity of trifluoromethylated olefins with indole: a mechanistic investigation, Tetrahedron Lett. 2012, 53, 2132-2136.

 

Beatriz Díaz Reinoso, Ana Gomes, Marisa Freitas, Eduarda Fernandes, Daniele Rubert, José González, Andrés Moure, Argimiro Levoso, María Pilar Vinardell, Montserrat Mitjans, Herminia Domínguez, Juan Carlos Parajó, Valuable polyphenolic antioxidants from wine vinasses, Food Bioprocess Technol. 2012, 5, 2708-2716.

 

Ana Gomes, Diana Couto, Andreia Alves, Irene Dias, Marisa Freitas, Graça Porto, José Alberto Duarte, Eduarda Fernandes, Trihydroxyflavones with antioxidant and anti-inflammatory efficacy, Biofactors 2012, 38(5), 378-386.

 

Renan Campos Chisté, Marisa Freitas, Adriana Zerlotti Mercadante, Eduarda Fernandes, The potential of extracts of Caryocar villosum pulp to scavenge reactive oxygen and nitrogen species, Food Chem. 2012, 135, 1740-1749.

 

Mónica S. Estevão, Luísa C. Carvalho, Marisa Freitas, Ana Gomes, Aldino Viegas, João Manso, Stefan Erhardt, Eduarda Fernandes, Eurico J. Cabrita, M. Manuel B. Marques, Indole based cyclooxygenase inhibitors: synthesis, biological evaluation, docking and NMR screening, Eur. J. Med. Chem. 2012, 54, 823-833.

 

Beatriz Días Reinoso, Diana Couto, Andrés Moure, Eduarda Fernandes, Herminia Domíguez, Juan Carlos Parajó, Optimization of antioxidants – Extraction from Castanea sativa leaves, Chem. Eng. J. 2012, 203, 101-109.

 

Mara Ribeiro Almeida, Darin, J.D.C.; Hernandes, L.C.; Aissa, A.F.; Renan Campos Chisté, Adriana Z. Mercadante, Antunes, L.M.G.; Bianchi, M.L.P. Antigenotoxic effects of piquiá (Caryocar villosum) in multiple rat organs. Plant Foods Hum. Nutr., 67, 171-177, 2012.

 

Renan Campos Chisté, Adriana Z. Mercadante. Identification and quantification, by HPLC-DAD-MS/MS, of carotenoids and phenolic compounds from the Amazonian fruit Caryocar villosum. J. Agric. Food Chem., 60, 5884-5892, 2012.

 

Eliseu Rodrigues, Lilian R. B. Mariutti, Renan Campos Chisté, Adriana Z. Mercadante. Development of a novel micro-assay for evaluation of peroxyl radical scavenger capacity: application to carotenoids and structure-activity relationship. Food Chem., 136, 1-10, 2012.

 

 

2011

 

Paula Silva, L.M.P. Valente, M. Olmedo, B. Álvarez-Blázquez, M.H. Galante, R.A.F. Monteiro, E. Rocha. Influence of temperature on muscle fiber hyperplasia and hypertrophy in larvae of blackspot seabream, Pagellus bogaraveo.Aqua. Res. 2011, 42, 331-340.

 

Mónica S. Estevão, Luísa C. Carvalho, Luísa M. Ferreira, Eduarda Fernandes, M. Manuel B. Marques, Analysis of the antioxidant activity of an indole library: cyclic voltammetry vs ROS scavenging activity, Tetrahedron Lett. 2011, 52, 101-106.

 

Karsten Ruscher, Eduarda Fernandes, João Capela, Maria de Lourdes Bastos, Tadeusz W. Wieloch, Ulrich Dirnagl, Andreas Meisel, Felix Carvalho, Effect of 3,4-methylenedioxyamphetamine on dendritic spines dynamics in rat neocortical neurons - Involvement of heat shock protein 27, Brain Res. 2011, 1370, 43-52.

 

Renan Campos Chisté, Adriana Zerlotti Mercadante, Ana Gomes, Eduarda Fernandes, José Luís Fontes Costa Lima, Neura Bragagnolo, In vitroscavenging capacity of annatto seed extracts against reactive oxygen and nitrogen species, Food Chem. 2011, 127(2), 419-426.

 

Renan Campos Chisté, Marta T. Benassi, Adriana Z. Mercadante. Effect of solvent type on the extractability of bioactive compounds, antioxidant capacity and colour properties of natural annatto extracts. Inter. J. Food Sci. Technol., 46, 1863-1870, 2011.

 

Luísa R. Carvalho, Eduarda Fernandes, M. Manuel B. Marques, Developments towards regioselective synthesis of 1,2-disubstituted benzimidazoles, Chem.-Eur. J. 2011, 17, 12544-12555.

 

Marisa Freitas, Eduarda Fernandes, Zinc, cadmium and nickel increased the activation of NF-κB and the release of cytokines from THP-1 monocytic cell, Metallomics 2011, 3, 1238-1243.

 

João Martins, Miguel Castelo-Branco, Ana Batista, Bárbara Oliveiros, Ana Raquel Santiago, Joana Galvão, Eduarda Fernandes, Félix Carvalho, Cláudia Cavadas, António F. Ambrósio, Effects of 3,4-methylenedioxymeth-amphetamine administration on retinal physiology in the rat, PLoS one 2011, 6(12), e29583.